In New Eden, Martin unsuccessfully tries to protect his wife and daughter from an attack of vampires led by a blonde vampire. He returns to North America to seek out the vampire hunter Mister to help him to destroy the vampire leader. Along his journey, he stumbles upon dangerous survivors and the notorious brotherhood; but he also finds a new community with good people that welcome him. But Martin is seeking out revenge.

Ace is just like any other new kid at school, until his grandfather from Transylvania dies at age 96 and sends him his dog Fang. Ace soon discovers that Fang is a vampire dog - and he speaks English! Mad scientist Dr. Warhol and her bumbling assistant Frank try to capture Fang and steal his DNA in hopes of developing the latest anti-aging technology, but lucky for Ace the vampire dog manages to stay one step ahead of his pursuers. Along the way an enduring friendship forms when Ace and Fang discover that together they are unstoppable.